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KMID : 0370920070240020252
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Yeungnam Univercity Journal of Medicine
2007 Volume.24 No. 2 p.252 ~ p.261
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Association Analyses of beta3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean
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Jung Hong-Soo
Lee Joo-Hyun
Sakong Joon
Bae Sung-Wook
Kim Jung-Hye
Kim Jae-Ryong
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Abstract
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Background : Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors.
Materials & Methods : In an attempt to investigate the association of obesity with its candidate genes, beta3 adrenergic receptor (beta3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of beta3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects.
Results : The Trp64Arg polymorphism in the beta3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects.
Conclusion : These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the beta3AR Trp64Arg polymorphism.
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KEYWORD
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Obesity, Beta-3 adrenergic receptor, Uncoupling protein 2, Polymorphism, Body Mass Index
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